3426 Comparison of the efficacy of different topical non-steroidal drops as pain relief following excimer laser P.R.K.

pumose To compare the efficacy of topical indomethicin, dicMenac and ketorolac as pain relief following excimer laser P.R.K. &&Q&s Double masked, random&d trial involving 360 patients. Au patients rece.ived a standard regime of one of the trial dmgs and chloramphenicol ointment to be used four times daily for 3 days. Pain levels were assessed on B I ocm linear aMlogue scale prior to each instillation of the topical medication. Patients were advised to use. paracetamol as additional pain relief but were allowed to use any oral analgesia ( except non-steroidal agents ) which they documented ( type and quantity ). Qmlity of sleep was graded. A comparison of end r&action and haze levels is made. &&g ‘Ihere was no significant diffe.re.nce in pain scores between the groups using diclofenso and k&xc&. Ketorolac was signiticantly better than indomethicin for pain relief at hours I8 and 60 ( p<O.Ol ); while diclofenac was signi&mtly better than indometbicin at hour 18 ( p<O.Ol ). COnClUSiOU In this tidy, there is no significant di&rence between topical ketorolac and diclofenac as pain relief following mimer laser PRK. Both of these drugs are signiticantly better than topical indonwtbicia